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KMID : 0363320100310030631
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Journal of Korean Oriental Internal Medicine
2010 Volume.31 No. 3 p.631 ~ p.649
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Effects of Chunglijagam-tang Aqueous Extracts on Streptozotocin-induced Rat Diabetes and Related Complications
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Park Yoon-Sik
Yoon Keong-Min
Im Eun-Young
Shin Hyeon-Cheol
Kang Suk-Bong
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Abstract
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Objective:The object of this study was to observe the effects of aqueous extracts of Chunglijagam-tang(CLJGT), which has traditionally been used in Korean medicine for treating various diseases, on streptozotocin(STZ)-induced rat diabetes and related complications: diabetic nephropathy, hepatopathy and hyperlipemia.
Methods:CLJGT extracts were orally administered once a day for 28 days at a dosage 50, 100 and 200mg/kg from 21 days after STZ treatment, and the changes on body weights, blood glucose levels, kidney and liver weights, serum BUN(blood urea nitrogen), creatinine, AST(aspartate transaminase), ALT(alanine aminotransferase), HDL(high-density lipoprotein), LDL (low-density lipoprotein), total cholesterol and triglyceride levels were observed with pancreatic malondialdehyde(MDA) and glutathione(GSH) contents. The results were compared with silymarin 100mg/kg.
Results:Significant decrease of blood glucose levels, kidney and liver weights, serum BUN, creatinine, AST, ALT, LDL, total cholesterol, triglyceride levels, pancreatic malondialdehyde contents and significant increase of body weights, serum HDL levels, pancreatic glutathione contents were detected in CLJGT extracts 50, 100 and 200mg/kg administered groups as compared to the STZ control group.
Conclusion:CLJGT extracts showed favorable effects on the STZ-induced diabetes and related complications mediated by their antioxidant effects as similar to silymarin. Therefore, it is expected that DBEH has potential for use in the management of diabetes and various diabetic complications.
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KEYWORD
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Chunglijagam-tang(Qinglizikan-tang), diabetes, hyperlipemia, antioxidant, silymarin
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